Pilot Study on Light Dosimetry Variables for Photodynamic Therapy of Barrett's Esophagus with High-Grade Dysplasia

  title={Pilot Study on Light Dosimetry Variables for Photodynamic Therapy of Barrett's Esophagus with High-Grade Dysplasia},
  author={Kanwar Gill and Herbert C. Wolfsen and Norris W. Preyer and M V Scott and Seth A. Gross and Michael B. Wallace and Linda Ramball Jones},
  journal={Clinical Cancer Research},
  pages={1830 - 1836}
Purpose: Photodynamic therapy (PDT) is used to treat Barrett's esophagus with high-grade dysplasia and mucosal carcinoma. Outcomes are variable with some patients having persistent disease, whereas others develop strictures. The aims of this study were (a) to compare porfimer sodium tissue uptake, light dose, and esophageal thickness with clinical outcomes and (b) to determine the selectivity of porfimer sodium uptake in diseased and normal epithelium. Experimental Design: Forty-eight hours… 
Variables in photodynamic therapy for Barrett's esophagus
  • L. Jones, N. Preyer, +4 authors K. Gill
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    World Congress of the International Photodynamic Association
  • 2009
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  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2008
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This preliminary experience with Nd:YAG contact laser for the treatment of Barrett's HGD and early superficial cancers seems promising, but the need for additional controlled trials with larger numbers of patients with longer follow-up is warranted.
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An improved method to estimate dose to esophageal tissue was investigated in the setting of photodynamic therapy with aminolevulinic acid‐induced protoporphyrin IX (PpIX) treatment, and a correlation was shown to exist between this metric and the edema induced in the esophagus.