Pilot Study on Light Dosimetry Variables for Photodynamic Therapy of Barrett's Esophagus with High-Grade Dysplasia

@article{Gill2009PilotSO,
  title={Pilot Study on Light Dosimetry Variables for Photodynamic Therapy of Barrett's Esophagus with High-Grade Dysplasia},
  author={Kanwar Gill and Herbert C. Wolfsen and Norris W. Preyer and M V Scott and Seth A. Gross and Michael B. Wallace and Linda Ramball Jones},
  journal={Clinical Cancer Research},
  year={2009},
  volume={15},
  pages={1830 - 1836}
}
Purpose: Photodynamic therapy (PDT) is used to treat Barrett's esophagus with high-grade dysplasia and mucosal carcinoma. Outcomes are variable with some patients having persistent disease, whereas others develop strictures. The aims of this study were (a) to compare porfimer sodium tissue uptake, light dose, and esophageal thickness with clinical outcomes and (b) to determine the selectivity of porfimer sodium uptake in diseased and normal epithelium. Experimental Design: Forty-eight hours… 
Variables in photodynamic therapy for Barrett's esophagus
  • L. Jones, N. Preyer, +4 authors K. Gill
  • Materials Science, Engineering
    World Congress of the International Photodynamic Association
  • 2009
Photodynamic therapy with porfimer sodium (PS) is a treatment option for high grade dysplasia associated with Barrett's esophagus. This study sought to investigate the optical properties of Barrett's
Comparison of endoscopic treatment modalities for Barrett's neoplasia.
TLDR
This study of endoscopic treatment for Barrett's dysplasia and neoplasia found that complete remission was achieved more often and more rapidly after Ps-PDT with similar disease recurrence rates compared with EMR or RFA.
The role of photodynamic therapy in the esophagus.
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Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions
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An overview of the clinical trials conducted over the last 10 years is provided, illustrating how PDT is applied in the clinic today, and the factors that hamper the exploration of this effective therapy and what should be changed to render it a more effective and more widely available option for patients.
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The most important biological and physicochemical aspects of photodynamic therapy are addressed, its clinical status is summarized, and an outlook for its potential future development is provided.
Oxidative Stress and Photodynamic Therapy for Prostate Cancer
Photodynamic therapy (PDT) takes advantage of the generation of reactive oxygen species and subsequent oxidative effects to generate focal tissue damage. It involves the local activation of a
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