Pilot Study of Estramustine Added to Radiosurgery and Radiotherapy for Treatment of High Grade Glioma

@article{Landy2004PilotSO,
  title={Pilot Study of Estramustine Added to Radiosurgery and Radiotherapy for Treatment of High Grade Glioma},
  author={Howard Landy and Arnold M. Markoe and Priscilla Potter and Garrett Lasalle and Angela Marini and Niramol Savaraj and Isildinha Reis and Deborah O. Heros and Medhi Wangpaichitr and Lynn G Feun},
  journal={Journal of Neuro-Oncology},
  year={2004},
  volume={67},
  pages={215-220}
}
  • Howard Landy, Arnold M. Markoe, +7 authors Lynn G Feun
  • Published in Journal of Neuro-Oncology 2004
  • Medicine
  • Patients with high grade glioma generally have poor prognoses. Addition of radiosensitizing agents might improve the response to irradiation. The chemotherapeutic agent estramustine sensitizes experimental gliomas to radiation. Gliomas express estramustine binding proteins, and cytotoxic concentrations of estramustine metabolites are found in gliomas after oral administration. Twenty three patients, aged 25–78, with new or recurrent high grade glioma were treated with estramustine and… CONTINUE READING

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