Pilot Scale-up of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Production by Halomonas bluephagenesis via Cell Growth Adapted Optimization Process.

@article{Ye2018PilotSO,
  title={Pilot Scale-up of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Production by Halomonas bluephagenesis via Cell Growth Adapted Optimization Process.},
  author={Jianwen Ye and Wuzhe Huang and Dongsheng Wang and Feng Chen and Jin Yin and Teng Li and Haoqian M Zhang and Guoqiang Chen},
  journal={Biotechnology journal},
  year={2018},
  volume={13 5},
  pages={
          e1800074
        }
}
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate), P(3HB-co-4HB), is one of the most valuable biopolymers because of its flexible mechanical properties. In this study, the goal is to establish a scaled-up process of low cost P(3HB-co-4HB) from a 7.5-L fermentor to 1- and 5-m3 industrial bioreactors, respectively, using Halomonas bluephagenesis TD40 grown on glucose, γ-butyrolactone, and waste corn steep liquor (CSL) as substrates, under open non-sterile and fed-batch or continuous conditions. The… 
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Improved nutrient feeding strategy, acetic acid induction, and oleic acid supplementation were used and resulted in a high level of productivity in production of high concentrations and high contents of P(3HB-co-3HV) in a chemically defined medium.
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The physiological functions of PHB as a reserve material and in symbiotic nitrogen fixation and its presence in bacterial plasma membranes and putative role in transformability and calcium signaling are also considered.
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