Pilot Evaluation of Anti-1-amino-2-[18F] fluorocyclopentane-1-carboxylic acid (anti-2-[18F] FACPC) PET-CT in Recurrent Prostate Carcinoma

@article{SavirBaruch2010PilotEO,
  title={Pilot Evaluation of Anti-1-amino-2-[18F] fluorocyclopentane-1-carboxylic acid (anti-2-[18F] FACPC) PET-CT in Recurrent Prostate Carcinoma},
  author={Bital Savir-Baruch and David M. Schuster and Nashwa Jarkas and Viraj A. Master and Peter T. Nieh and Raghuveer K. Halkar and Jonathon A. Nye and Melinda M. Lewis and Ronald J. Crowe and Ronald J. Voll and Vernon M. Camp and Leah M. Bellamy and David Leland Roberts and Mark M. Goodman},
  journal={Molecular Imaging and Biology},
  year={2010},
  volume={13},
  pages={1272-1277}
}
Anti-1-amino-2-[18F]fluorocyclopentane-1-carboxylic acid (anti-2-[18F]FACPC) is an unnatural alicyclic amino acid radiotracer with high uptake in the DU-145 prostate cancer cell line in vitro. Our goal was to determine if anti-2-[18F]FACPC is useful in the detection of prostate carcinoma. Five patients with elevated PSA (1.1–20.5 ng/mL) after curative therapy for prostate carcinoma underwent 60 min dynamic positron emission tomography (PET) of the pelvis after IV injection of 193–340 MBq of… CONTINUE READING

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