Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres.

@article{Slatter2010PilocyticAH,
  title={Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres.},
  author={Tania L. Slatter and Jennifer Gifford-Garner and Anna K. Wiles and X. M. Tan and Yu-Jen Chen and Martin MacFarlane and Michael Sullivan and Janice Royds and Noelyn Hung},
  journal={The American journal of pathology},
  year={2010},
  volume={177 6},
  pages={2694-700}
}
Telomere maintenance by either telomerase activity or the recombination-mediated alternative lengthening of telomeres (ALT) mechanism is a hallmark of cancer. Tumors that use ALT as their telomere maintenance mechanism are characterized by long telomeres of great heterogeneity in length and by specific nuclear structures of co-localized promyelocytic leukemia protein and telomere DNA, called ALT-associated promyelocytic leukemia bodies (APBs). Recent advances have revealed a direct role for… CONTINUE READING

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