Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia).

  title={Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia).},
  author={Philip C. Fox and J C Atkinson and A A Macynski and Andrew Wolff and David S. Kung and I H Valdez and William G Jackson and Robert Delapenha and J. Shiroky and B J Baum},
  journal={Archives of internal medicine},
  volume={151 6},
We studied the effects of pilocarpine hydrochloride, a para-sympathomimetic agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a double-blind fashion. Objective measurements of major salivary gland output, subjective impressions of oral moisture, treatment-related side effects, and a number of physiologic… CONTINUE READING


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