Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group.

@article{Vivino1999PilocarpineTF,
  title={Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sj{\"o}gren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group.},
  author={Frederick B. Vivino and Ibtisam H Al-Hashimi and Zahir Khan and Fran G Leveque and Pavana Lord Salisbury and Tram K Tran-Johnson and Charles C Muscoplat and Madhu Trivedi and Barry Goldlust and Susan C Gallagher},
  journal={Archives of internal medicine},
  year={1999},
  volume={159 2},
  pages={174-81}
}
BACKGROUND Patients with Sjögren syndrome (SS) experience slowly progressive infiltration of lacrimal and salivary glands by mononuclear cells. This leads to diminished secretions, with resultant symptoms of xerostomia and xerophthalmia. Although pilocarpine hydrochloride tablets are currently indicated for the treatment of radiation-induced xerostomia, their effects on dry mouth or dry eyes in patients with SS are unclear. OBJECTIVE To assess the safety and efficacy of pilocarpine (Salagen… CONTINUE READING

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