Pilocarpine-induced reciprocal hindlimb scratching in mice.

  title={Pilocarpine-induced reciprocal hindlimb scratching in mice.},
  author={Randy W. Scott and Tamara L Goode and Robert B Raffa},
  journal={Pharmacology, biochemistry, and behavior},
  volume={26 2},
Intrathecal (IT) administration of pilocarpine (0.25-2.0 micrograms) to mice produced a vigorous and dose-related reciprocal hindlimb scratching response that lasted for 10-15 minutes. Neither the intracerebroventricular administration of pilocarpine at up to 10 times the intrathecal ED90 dose nor the subcutaneous administration of 10 mg/kg pilocarpine caused as robust an effect as IT administration. The reciprocal hindlimb scratching produced by the ED90 dose of pilocarpine (2 micrograms, IT… CONTINUE READING