Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin.

@article{Abbot2007PiliMS,
  title={Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin.},
  author={Emily L Abbot and Wendy D. Smith and Gerard P S Siou and Carlos Andr{\'e}s Chiriboga and Rebecca J Smith and Janet A. Wilson and Barry Hugo Hirst and Michael A. Kehoe},
  journal={Cellular microbiology},
  year={2007},
  volume={9 7},
  pages={1822-33}
}
Very little is known about the biological functions of pili that have recently been found to be expressed by important Gram-positive pathogens such as Corynebacterium diphtheriae, Streptococcus agalacticae, S. pneumoniae and S. pyogenes. Using various ex vivo tissue and cellular models, here we show that pili mediate adhesion of serotype M1 S. pyogenes strain SF370 to both human tonsil epithelium and primary human keratinocytes, which represent the two main sites of infection by this human… CONTINUE READING
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