Pilgrim Trust Lecture - The gene

@article{Muller1947PilgrimTL,
  title={Pilgrim Trust Lecture - The gene},
  author={Hermann Joseph Muller},
  journal={Proceedings of the Royal Society of London. Series B - Biological Sciences},
  year={1947},
  volume={134},
  pages={1 - 37}
}
  • H. Muller
  • Published 7 January 1947
  • Philosophy
  • Proceedings of the Royal Society of London. Series B - Biological Sciences
The gene has sometimes been described as a purely idealistic concept, divorced from real things, and again it has been denounced as wishful thinking on the part of those too mechanically minded. And some critics go so far as to assert that there is not even such a thing as genetic material at all, as distinct from other constituents of living matter. 
The gene in search of an identity
TLDR
Without much heart-seeking among geneticists, the gene regained its role as an instrumental unit, or even as just an intervening variable, “a quantity obtained by specified manipulation of the values of empirical variables” within less than 20 years.
What is a gene? - Revisited.
  • R. Falk
  • Biology
    Studies in history and philosophy of biological and biomedical sciences
  • 2010
Hermann Joseph Muller, Evolutionist
  • J. Crow
  • Education
    Nature Reviews Genetics
  • 2005
This essay is dedicated to the proposition that Hermann Joseph Muller, widely regarded as the greatest geneticist of the first half-century of the subject, was also one of the greatest evolutionists
Alexandr I. Oparin and the Origin of Life: A Historical Reassessment of the Heterotrophic Theory
  • A. Lazcano
  • Physics
    Journal of Molecular Evolution
  • 2016
TLDR
The development of Oparin’s views and the ensuing debates cannot be understood without considering the confrontation between Mendelism and Darwinism during the first three decades of the past century, combined with the doubts surrounding the existence of genes.
Genetic Analysis: A History of Genetic Thinking
TLDR
From reproduction and generation to heredity, the chromosome theory of inheritance and Faktoren in search of meaning, which explains why E. coli is not true for the elephant.
To What Inanimate Matter Are We Most Closely Related and Does the Origin of Life Harbor Meaning?
The question concerning the meaning of life is important, but it immediately confronts the present authors with insurmountable obstacles from a philosophical standpoint, as it would require us to
Reply to H. V. Wyatt
WYATT's inference1 that Avery's work on pneumococcal transformation was not well recognized by geneticists in the decade following his 1944 report2 is somewhat at odds with my own recollection and
H. J. Muller's role in evolutionary biology
TLDR
M Muller regularly taught a course in evolution, which started with the origins of the universe and of the solar system and ended with science fiction-like speculation about, and hopes for, the future of human evolution.
Oswald Avery, DNA, and the transformation of biology
Gene Structure and Gene Action
During the past several years there have been developments that have profoundly changed current thinking about the structure, reproduction, mutation and function of genes. It is the author’s purpose
...
...

References

SHOWING 1-8 OF 8 REFERENCES
Heredity, Development and Infection
TLDR
The development of genetics has depended on the separation between determinants and what they determine, between factor and character, between gene and gene-product, between genotype and phenotype.
Genetics as a Tool for Studying Gene Structure
By making use of current ideas about the structure of genes it is possible to develop a formal scheme which will account for the continuity of genic specificity in gene reproduction, and for the
Increased Alkaloidal Contents of Induced Polyploids of Datura
TETRAPLOID plants of various species of Atropa, Datura and Hyoscyamus have been produced by the treatment of their seeds with colchicine solution; polyploidy being judged by the sizes of stomata or
TRANSFORMATION OF SWINE PEPSINOGEN INTO SWINE PEPSIN BY CHICKEN PEPSIN
TLDR
The structure responsible for the species specificity of the enzyme is present in the inactive precursor of the pepsinogen.
A Reconsideration of the Mechanism of Position Effect.
  • B. Ephrussi, E. Sutton
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1944
-6 Quoted from Muller, H. J., Cold Spring Harbor Symposia on Quantitative Biology, 9, 290-308 (1941). 7Stutrtevant, A. H., the preceding paper in these PROCEEDINGS. 8 Reimann, H. A., Jour. Exp. Med.,
THE STRUCTURE OF THE CHROMOSOMES IN THE SALIVARY GLANDS OF DROSOPHILA.