PilF is an outer membrane lipoprotein required for multimerization and localization of the Pseudomonas aeruginosa Type IV pilus secretin.

@article{Koo2008PilFIA,
  title={PilF is an outer membrane lipoprotein required for multimerization and localization of the Pseudomonas aeruginosa Type IV pilus secretin.},
  author={Jason Koo and Stephanie Tammam and Shao-Yang Ku and Liliana M Sampaleanu and Lori L Burrows and P Lynne Howell},
  journal={Journal of bacteriology},
  year={2008},
  volume={190 21},
  pages={6961-9}
}
Type IV pili (T4P) are retractile appendages that contribute to the virulence of bacterial pathogens. PilF is a Pseudomonas aeruginosa lipoprotein that is essential for T4P biogenesis. Phenotypic characterization of a pilF mutant confirmed that T4P-mediated functions are abrogated: T4P were no longer present on the cell surface, twitching motility was abolished, and the mutant was resistant to infection by T4P retraction-dependent bacteriophage. The results of cellular fractionation studies… CONTINUE READING
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