Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation

@article{Sato2008PikachurinAD,
  title={Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation},
  author={Shigeru Sato and Y. Omori and K. Katoh and M. Kondo and M. Kanagawa and Kentaro Miyata and K. Funabiki and Toshiyuki Koyasu and N. Kajimura and T. Miyoshi and H. Sawai and Kazuhiro Kobayashi and A. Tani and T. Toda and J. Usukura and Y. Tano and T. Fujikado and T. Furukawa},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={923-931}
}
Exquisitely precise synapse formation is crucial for the mammalian CNS to function correctly. Retinal photoreceptors transfer information to bipolar and horizontal cells at a specialized synapse, the ribbon synapse. We identified pikachurin, an extracellular matrix–like retinal protein, and observed that it localized to the synaptic cleft in the photoreceptor ribbon synapse. Pikachurin null-mutant mice showed improper apposition of the bipolar cell dendritic tips to the photoreceptor ribbon… Expand
221 Citations
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