Pii: S0304-3835(98)00306-1


Adriamycin (ADM) is a broad-spectrum antineoplastic antibiotic used to treat cancer patients. However, the usefulness of this drug is presently limited by the development of a dose-dependent cardiotoxicity. A current hypothesis for the ADMinduced cardiotoxicity is the production of reactive oxygen radicals by the drug. We utilized the ̄uorescent indicator… (More)


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