Pigmentary type of orthochromatic leukodystrophy (OLD): a new case with ultrastructural and biochemical study.

@article{Gray1987PigmentaryTO,
  title={Pigmentary type of orthochromatic leukodystrophy (OLD): a new case with ultrastructural and biochemical study.},
  author={Françoise Gray and Alain Dest{\'e}e and J. M. Bourre and Romain Kroum Gherardi and Ivan Krivosic and P. Warot and Jacques Poirier},
  journal={Journal of neuropathology and experimental neurology},
  year={1987},
  volume={46 5},
  pages={585-96}
}
A 34-year-old woman with no family history of orthochromatic leukodystrophy (OLD) developed progressive intellectual deterioration, a frontal syndrome and spastic tetraparesis. She died four years after the onset of the clinical illness. Neuropathological studies included light and electron microscopy of cerebral and nerve biopsies, and a complete postmortem examination. Light microscopy demonstrated OLD with pigmented macrophages and glial cells. Electron microscopy showed electron-dense… CONTINUE READING

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