Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its antioxidative properties.

@article{Yamagishi2002PigmentEF,
  title={Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its antioxidative properties.},
  author={Sho-ichi Yamagishi and Yosuke Inagaki and Shinjiro Amano and Tamami Okamoto and Masayoshi Takeuchi and Zenji Makita},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={296 4},
  pages={877-82}
}
Pigment epithelium-derived factor (PEDF) has recently been shown to be the most potent inhibitor of angiogenesis in the mammalian eye, suggesting that loss of PEDF is involved in the pathogenesis of proliferative diabetic retinopathy. However, a protective role for PEDF in pericyte loss in early diabetic retinopathy remains to be elucidated. In this study, we investigated whether PEDF proteins could protect against advanced glycation end product (AGE)-induced injury in retinal pericytes. Ligand… CONTINUE READING

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