Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons.

@article{Houenou1999PigmentEF,
  title={Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons.},
  author={Lucien J. Houenou and Ashwin D'Costa and Lihua Li and Victoria L. Turgeon and C Enyadike and Elena Alberdi and S. Patricia Becerra},
  journal={The Journal of comparative neurology},
  year={1999},
  volume={412 3},
  pages={506-14}
}
Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor (serpin) superfamily that has been shown previously to promote the survival and/or differentiation of rat cerebellar granule neurons and human retinoblastoma cells in vitro. However, in contrast to most serpins, PEDF has no inhibitory activity against any known proteases, and its described biological activities do not appear to require the serpin-reactive loop located toward the carboxy end of the polypeptide… CONTINUE READING
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