Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration.

@article{Holekamp2002PigmentEF,
  title={Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration.},
  author={Nancy M. Holekamp and Noel P. Bouck and Olga V. Volpert},
  journal={American journal of ophthalmology},
  year={2002},
  volume={134 2},
  pages={220-7}
}
PURPOSE Pigment epithelium-derived growth factor (PEDF) is a potent inhibitor of angiogenesis that is found in the normal eye. The purpose of this study is to report decreased levels of PEDF in the vitreous of eyes with choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). DESIGN Prospective case-control study. METHODS In a prospective case-control study, undiluted vitreous was collected from nine eyes of nine patients with CNV due to AMD and from an age-matched… CONTINUE READING

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