Pigment epithelium-derived factor inhibits vascular endothelial growth factor-induced vascular hyperpermeability both in vitro and in vivo.

Abstract

Administration of pigment epithelium-derived factor (PEDF) inhibits advanced glycation end products-elicited retinal vascular hyperpermeability, as well as cold injury-induced brain oedema in rats. However, the underlying molecular mechanism by which PEDF blocks the hyperpermeability in vivo is not fully understood. This study investigated whether PEDF… (More)

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Cite this paper

@article{Yamagishi2007PigmentEF, title={Pigment epithelium-derived factor inhibits vascular endothelial growth factor-induced vascular hyperpermeability both in vitro and in vivo.}, author={Sho-ichi Yamagishi and Riichiro Abe and Yuko Jinnouchi and Takanori Matsui and Tadaatsu Imaizumi and Hiroshi Inoue}, journal={The Journal of international medical research}, year={2007}, volume={35 6}, pages={896-9} }