Pigment epithelium-derived factor inhibits advanced glycation end-products-induced cytotoxicity in retinal pericytes.

AIM This study investigated the effects of pigment epithelium-derived factor (PEDF) on advanced glycation end-product (AGE)-induced cytotoxicity in porcine retinal pericytes and the signalling mechanism involved. METHODS Retinal pericytes were isolated from porcine eyes and characterized by immunocytochemistry. The effect of AGEs and PEDF on cell… (More)