Pigment epithelium-derived factor gene therapy targeting retinal ganglion cell injuries: neuroprotection against loss of function in two animal models.

@article{Miyazaki2011PigmentEF,
  title={Pigment epithelium-derived factor gene therapy targeting retinal ganglion cell injuries: neuroprotection against loss of function in two animal models.},
  author={M. Miyazaki and Y. Ikeda and Y. Yonemitsu and Y. Goto and Y. Murakami and N. Yoshida and T. Tabata and M. Hasegawa and S. Tobimatsu and K. Sueishi and T. Ishibashi},
  journal={Human gene therapy},
  year={2011},
  volume={22 5},
  pages={
          559-65
        }
}
Lentiviral vectors are promising tools for the treatment of chronic retinal diseases including glaucoma, as they enable stable transgene expression. We examined whether simian immunodeficiency virus (SIV)-based lentiviral vector-mediated retinal gene transfer of human pigment epithelium-derived factor (hPEDF) can rescue rat retinal ganglion cell injury. Gene transfer was achieved through subretinal injection of an SIV vector expressing human PEDF (SIV-hPEDF) into the eyes of 4-week-old Wistar… Expand
35 Citations
Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells.
Pigment Epithelium-Derived Factor Released by Müller Glial Cells Exerts Neuroprotective Effects on Retinal Ganglion Cells
Effects of pigment epithelium-derived factor on traumatic brain injury.
...
1
2
3
4
...

References

SHOWING 1-10 OF 40 REFERENCES
Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model.
Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor.
Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice
Stable retinal gene expression in nonhuman primates via subretinal injection of SIVagm-based lentiviral vectors.
Pigment epithelium-derived factor protects retinal ganglion cells
Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury
AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells
...
1
2
3
4
...