Pigment epithelium-derived factor gene loaded in cRGD-PEG-PEI suppresses colorectal cancer growth by targeting endothelial cells.

@article{Li2012PigmentEF,
  title={Pigment epithelium-derived factor gene loaded in cRGD-PEG-PEI suppresses colorectal cancer growth by targeting endothelial cells.},
  author={Lei Li and Jun Yang and Wei-Wei Wang and Ya-Chao Yao and Shu-Huan Fang and Zhi-Yu Dai and Hong-Hai Hong and Xia Yang and Xin-tao Shuai and Guoquan Gao},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={438 1-2},
  pages={1-10}
}
Pigment epithelium-derived factor (PEDF) recombinant protein has been investigated in many kinds of solid tumors due to its potent antiangiogenic activity. However, the complexity of protein purification, instability of recombinant protein and requirement of repeated injections are obstacles for the recombinant PEDF therapy for solid tumors. We successfully synthesized polyethyleneglycol-polyetherimide (PEG-PEI) and cRGD-PEG-PEI which was coupled with a cyclic RGD peptide, a special ligand for… CONTINUE READING