Pigment epithelium-derived factor decreases outflow facility.

@article{Rogers2013PigmentEF,
  title={Pigment epithelium-derived factor decreases outflow facility.},
  author={Morgan E. Rogers and I. Navarro and K. Perkumas and S. M. Niere and R. Allingham and C. Crosson and W. Stamer},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 10},
  pages={
          6655-61
        }
}
PURPOSE Pigment epithelium-derived factor (PEDF) regulates blood-retinal barrier function. As a constituent of aqueous humor, the role of PEDF in conventional outflow function is unknown. The goals of the study were to examine the effects of PEDF on barrier function of cultured Schlemm's canal (SC) endothelia and outflow facility in mouse eyes in situ. METHODS To model the inner wall of SC, transendothelial electrical resistance (TEER) of human SC and porcine angular aqueous plexus (AAP… Expand
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