Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site.


Pigment epithelium-derived factor (PEDF) is a multifunctional serpin with antitumorigenic, antimetastatic, and differentiating activities. PEDF is found within tissues rich in the glycosaminoglycan hyaluronan (HA), and its amino acid sequence contains putative HA-binding motifs. We show that PEDF coprecipitation with glycosaminoglycans in media conditioned… (More)
DOI: 10.1074/jbc.M801287200