Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells

@article{Famulla2011PigmentEF,
  title={Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells},
  author={Susanne Famulla and Daniela Lamers and Sunny Hartwig and Waltraud Passlack and Angelika Horrighs and Andrea Cramer and Stephan Lehr and Henrike Sell and J{\"u}rgen Eckel},
  journal={International Journal of Obesity},
  year={2011},
  volume={35},
  pages={762-772}
}
Objective:Pigment epithelium-derived factor (PEDF) is a multifunctional protein with neurotrophic and anti-angiogenic properties. More recently it became evident that PEDF is upregulated in patients with type 2 diabetes and also contributes to insulin resistance in mice. During characterization of the secretome of in vitro differentiated human adipocytes by two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization-MS, we found that PEDF is one of the… CONTINUE READING

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