Pigeon fanciers' lung: identification of disease-associated carbohydrate epitopes on pigeon intestinal mucin.

@article{Baldwin1999PigeonFL,
  title={Pigeon fanciers' lung: identification of disease-associated carbohydrate epitopes on pigeon intestinal mucin.},
  author={C. I. Baldwin and Adam Todd and Stephen J. Bourke and Andrew Strachan Allen and Jane E. Calvert},
  journal={Clinical and experimental immunology},
  year={1999},
  volume={117 2},
  pages={
          230-6
        }
}
Pigeon intestinal mucin, a complex high molecular weight glycoprotein, is a key antigen in the development of pigeon fanciers' lung (PFL). We have studied the specificity of antibodies to mucin in patients with PFL and asymptomatic antibody-positive individuals. Extensive papain digestion, which removes the non-glycosylated regions of the mucin leaving the heavily glycosylated 'bottle brush' regions, resulted in a 600-fold decrease in IgG3 antibody titres with little effect on IgG1 and IgG2… CONTINUE READING
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