Pig conceptuses secrete estrogen and interferons to differentially regulate uterine STAT1 in a temporal and cell type-specific manner.

@article{Joyce2007PigCS,
  title={Pig conceptuses secrete estrogen and interferons to differentially regulate uterine STAT1 in a temporal and cell type-specific manner.},
  author={Margaret M. Joyce and Robert C. Burghardt and Rodney D. Geisert and James R. Burghardt and R. Neil Hooper and Jason W. Ross and Morgan D. Ashworth and Greg A Johnson},
  journal={Endocrinology},
  year={2007},
  volume={148 9},
  pages={
          4420-31
        }
}
Conceptus trophectoderm and uterine luminal epithelial cells interact via endocrine, paracrine, and autocrine modulators to mediate pregnancy recognition and implantation. Pig conceptuses not only release estrogens for pregnancy recognition but also secrete interferons during implantation. Because interferon-stimulated genes are increased by interferons secreted for pregnancy recognition in ruminants, we asked whether the interferon-stimulated gene, STAT1, is up-regulated in pig endometrium by… 
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Interleukins, interferons, and establishment of pregnancy in pigs.
TLDR
Based on studies carried out in pigs and other mammals, the combined spacio-temporal activities of conceptus estrogens, IL1β, and IFN set in motion a series of coordinated events that promote establishment of pregnancy through enhancement of Conceptus development, uterine receptivity, maternal-fetal hemotropic exchange, and endometrial leukocyte function.
Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs
TLDR
Information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors is addressed, focusing on the roles of estrogen and IL1B during early pregnancy in pigs.
Transcriptomic analysis of interferon-γ-regulated genes in endometrial explants and their possible role in regulating maternal endometrial immunity during the implantation period in pigs, a true epitheliochorial placentation species.
Pig conceptuses secrete interferon gamma to recruit T cells to the endometrium during the peri-implantation period†
TLDR
The results provide new insights into the immunology of implantation to suggest that trophectoderm cells of pigs secrete IFNG to recruit various subpopulations of T cells to the endometrium to contribute to a controlled inflammatory environment that supports the active breakdown and restructuring of theendometrium in response to implantation of the conceptus.
Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways.
Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium.
TLDR
Investigating STAT1 transcript and protein expression, as well as its biological activity in bovine tissue and cells of endometrial origin, provides novel molecular insights into the biological functions of STAT1 in the various cells composing the endometrium during maternal pregnancy recognition and implantation.
Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.
TLDR
Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals.
Interferons and uterine receptivity.
TLDR
The potential roles of interferons (IFNs) in establishing uterine receptivity to implantation are focused on to develop approaches to enhance reproductive health and fertility in humans and domestic animals.
Conceptus interferon gamma is essential for establishment of pregnancy in the pig
TLDR
Results indicate conceptus IFNG production is essential in modulating the endometrial proinflammatory response for conceptus attachment and survival in pigs.
Cytokines from the pig conceptus: roles in conceptus development in pigs
TLDR
This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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