Pig Embryonic Pancreatic Tissue as a Source for Transplantation in Diabetes

Abstract

RESEARCH DESIGN AND METHODS—Considering that anti-CD40L was found to be thrombotic in humans, we sought to test alternative costimulatory blockade agents already in clinical use, including CTLA4-Ig, anti-LFA1, and anti-CD48. These agents were tested in conjunction with T-cell debulking by anti-CD4 and anti-CD8 antibodies or with conventional immunosuppressive drugs. Engraftment and functional development of E42 pig pancreatic tissue was monitored by immunohistology and by measuring pig insulin blood levels.

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Cite this paper

@inproceedings{TchorshYutsis2009PigEP, title={Pig Embryonic Pancreatic Tissue as a Source for Transplantation in Diabetes}, author={Dalit Tchorsh-Yutsis and Gil Hecht and Anna Aronovich and Elias Shezen and Yael Zlotnikov Klionsky and Chava Rosen and Rivka Bitcover and Smadar Eventov-Friedman and Helena Katchman and Sivan Cohen and Orna Tal and Oren Milstein and Hideo Yagita and Bruce R Blazar and Yair Reisner}, year={2009} }