Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping

@inproceedings{Dewar2010Pif1AE,
  title={Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping},
  author={James M. Dewar and David Lydall},
  booktitle={The EMBO journal},
  year={2010}
}
Essential telomere 'capping' proteins act as a safeguard against ageing and cancer by inhibiting the DNA damage response (DDR) and regulating telomerase recruitment, thus distinguishing telomeres from double-strand breaks (DSBs). Uncapped telomeres and unrepaired DSBs can both stimulate a potent DDR, leading to cell cycle arrest and cell death. Using the cdc13-1 mutation to conditionally 'uncap' telomeres in budding yeast, we show that the telomere capping protein Cdc13 protects telomeres from… CONTINUE READING
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