Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

  title={Piezo2 senses airway stretch and mediates lung inflation-induced apnoea},
  author={Keiko Nonomura and Seung-Hyun Woo and Rui B. Chang and Astrid Gillich and Zhaozhu Qiu and Allain G. Francisco and Sanjeev Sumant Ranade and Stephen D. Liberles and Ardem Patapoutian},
Respiratory dysfunction is a notorious cause of perinatal mortality in infants and sleep apnoea in adults, but the mechanisms of respiratory control are not clearly understood. Mechanical signals transduced by airway-innervating sensory neurons control respiration; however, the physiological significance and molecular mechanisms of these signals remain obscured. Here we show that global and sensory neuron-specific ablation of the mechanically activated ion channel Piezo2 causes respiratory… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 104 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…