Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

@article{Nonomura2017Piezo2SA,
  title={Piezo2 senses airway stretch and mediates lung inflation-induced apnoea},
  author={Keiko Nonomura and Seung-Hyun Woo and Rui B. Chang and Astrid Gillich and Zhaozhu Qiu and Allain G. Francisco and Sanjeev Sumant Ranade and Stephen D. Liberles and Ardem Patapoutian},
  journal={Nature},
  year={2017},
  volume={541},
  pages={176-181}
}
Respiratory dysfunction is a notorious cause of perinatal mortality in infants and sleep apnoea in adults, but the mechanisms of respiratory control are not clearly understood. Mechanical signals transduced by airway-innervating sensory neurons control respiration; however, the physiological significance and molecular mechanisms of these signals remain obscured. Here we show that global and sensory neuron-specific ablation of the mechanically activated ion channel Piezo2 causes respiratory… CONTINUE READING
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