Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model.

@article{Yin2013PicropodophyllinIT,
  title={Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model.},
  author={S C Yin and Wei Guo and Ze-Zhang Tao},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={439 1},
  pages={1-5}
}
Insulin-like growth factor-1 receptor (IGF-1R) is a cell membrane receptor with tyrosine kinase activity and plays important roles in cell transformation, tumor growth, tumor invasion, and metastasis. Picropodophyllin (PPP) is a selective IGF-1R inhibitor and shows promising antitumor effects for several human cancers. However, its antitumor effects in nasopharyngeal carcinoma (NPC) remain unclear. The purpose of this study is to investigate the antitumor activity of PPP in NPC using in vitro… CONTINUE READING