Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells

@inproceedings{Tomizawa2014PicropodophyllinAS,
  title={Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells},
  author={Minoru Tomizawa and Fuminobu Shinozaki and Yasufumi Motoyoshi and Takao Sugiyama and Shigenori Yamamoto and Makoto Sueishi},
  booktitle={Oncology letters},
  year={2014}
}
Resistance is one limitation of sorafenib in the treatment of hepatocellular carcinoma (HCC). Insulin-like growth factor-1 receptor (IGF-1R) is involved in cancer cell proliferation. To assess the potential synergistic antitumor effects of picropodophyllin (PPP), an IGF-1R inhibitor, HLF and PLC/PRL/5, HCC cells were treated with PPP alone or PPP in… CONTINUE READING