Picornavirus IRES: structure function relationship.

  title={Picornavirus IRES: structure function relationship.},
  author={Encarnaci{\'o}n Mart{\'i}nez-Salas and Olga Fern{\'a}ndez-Miragall},
  journal={Current pharmaceutical design},
  volume={10 30},
Picornavirus infections have been a challenging problem in human health. Genome organisation of picornavirus is unique in having a long, heavily-structured, multifunctional 5'untranslated region, preceding a single open reading frame from which all viral proteins are produced. Within the 5'leader, an internal region termed ribosome entry site (IRES) regulates viral protein synthesis in a 5'-independent manner. The IRES element itself is a distinctive feature of the picornavirus mRNAs, allowing… CONTINUE READING