Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease

@article{Ikeda2001PickbodylikeII,
  title={Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease},
  author={Kenji Ikeda and Haruhiko Akiyama and Tetsuaki Arai and Kuniaki Tsuchiya},
  journal={Acta Neuropathologica},
  year={2001},
  volume={103},
  pages={115-118}
}
In corticobasal degeneration (CBD), tau-positive cytoplasmic inclusions resembling Pick bodies (PBs) appear in the cerebral cortex. Tau immunoreactivity in PBs is expressed mainly on filamentous elements, whereas that of PB-like inclusions in CBD is expressed on granules, which are densely packed mainly in the periphery of inclusions. PBs are clearly detectable by conventional Bodian silver impregnation but negative for the Gallyas–Braak (G–B) method and for PS262, which recognizes… CONTINUE READING

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