Pick’s disease with Pick bodies combined with progressive supranuclear palsy without tuft‐shaped astrocytes: A clinical, neuroradiologic and pathological study of an autopsied case

  title={Pick’s disease with Pick bodies combined with progressive supranuclear palsy without tuft‐shaped astrocytes: A clinical, neuroradiologic and pathological study of an autopsied case},
  author={Lu-ning Wang and Ming-wei Zhu and Yanna Feng and Jian-Hua Wang},
We report clinical, neuroradiologic features, and neuropathologic findings of a 76‐year‐old man with coexistent Pick’s disease and progressive supranuclear palsy. The patient presented with loss of recent memory, abnormal behavior and change in personality at the age of 60. The symptoms were progressive. Three years later, repetitive or compulsive behavior became prominent. About 9 years after onset, he had difficulty moving and became bed‐ridden because of a fracture of his left leg. His… Expand
Pick's disease with neuronal four‐repeat tau accumulation in the basal ganglia, brain stem nuclei and cerebellum
The present case suggests that, although probably rare, some Pick's disease cases have non‐negligible 4R tau pathology in the subcortical nuclei, and that such 4R Tau pathology can affect the evaluation of the distribution of AT8‐positive tau disease pathology in Pick’s disease cases. Expand
Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia
A novel transgenic mouse strain (K3) that expresses human tau carrying the FTD mutation K369I develops a progressive histopathology that is reminiscent of that in human FTD with the K369i mutation, and together, the K3 mice are a unique model of FTD-associated Parkinsonism, with pathomechanistic implications for the human pathologic process. Expand
Research Advances in Pick's Disease: A New Biomarker Candidate
This data indicates thatPiD is a member of a group of heterogeneous neurodegenerative disorders with similar or related histopathologic and clinical features known as frontotemporal lobal degeneration or dementia (FTD), the fourth most common cause of dementia in the USA. Expand
Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms
A body of literature providing evidence that axonal pathology represents an early and common pathogenic event among human tauopathies is reviewed, and potential mechanistic pathways other than microtubule destabilization by which disease-related forms of tau may promote axonopathy are discussed. Expand
Brain [F-18]FDG PET for Clinical Dementia Workup: Differential Diagnosis of Alzheimer's Disease and Other Types of Dementing Disorders.
Brain PET imaging with [F-18]FDG remains a valuable component of dementia workup owing to its relatively low cost, differential diagnostic performance, widespread availability, and physicians' experience over more than 40 years since the initial development. Expand
Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology
The findings suggest that phosphorylation is an early event, likely preceding the cleavage of tau at D421, and proposes a scheme of early tau processing in these structures, similar to neurofibrillary tangles of AD. Expand
Functional neuroanatomy of the central noradrenergic system
  • E. Szabadi
  • Biology, Medicine
  • Journal of psychopharmacology
  • 2013
The central noradrenergic neurone, like the peripheral sympathetic neur one, is characterized by a diffusely arborizing terminal axonal network, of which the locus coeruleus (LC) is the most prominent. Expand


Presenile dementia with progressive supranuclear palsy tangles and Pick bodies: an unusual degenerative disorder involving the cerebral cortex, cerebral nuclei, and brain stem nuclei
Degeneration of heterogeneous systems in the central nervous system, with widespread distribution of argyrophilic neuronal fibrillary inclusions, was found in a patient with presenile dementia, suggesting that these inclusions may reflect a form of cytoskeletal disorganization, which is not entirely restricted to a single disease entity. Expand
Pick's Disease: A Modern Approach
Biochemical and immunocytochemical studies have demonstrated that abnormal tau proteins are the major structural components of Pick bodies, and a specific tau protein immunoblotting pattern different from that seen in Alzheimer's disease and certain other disorders has been suggested in some studies. Expand
Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
We present the preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993.Expand
Neuropathologic Overlap of Progressive Supranuclear Palsy, Pick's Disease and Corticobasal Degeneration
Despite significant overlap among the three neurodegenerative diseases examined, the morphological and regional differences suggest that each is a distinct pathophysiological entity. Expand
Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits.
The present findings indicate that the G389R mutation in Tau can cause a dementing condition that closely resembles Pick's disease. Expand
Astrocytic pathology in progressive supranuclear palsy: significance for neuropathological diagnosis
Although the absence of Tu-SA does not necessarily exclude the possibility of PSP,Tu-SA in the frontal lobe and putamen is highly suggestive for PSP. Expand
Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases
Four Japanese autopsy cases of the generalized variant of Pick's disease are investigated both clinically and pathologically, and the degree and distribution of the basal ganglia lesions, including the amygdala, striatum, pallidum, and substantia nigra are examined, to contribute not only to the elucidation of clinicopathological hallmarks, but also to the progress of neuroimaging. Expand
Maladie de Pick. Point de vue anatomo-clinique.
Pick's disease is characterized by a circumscribed fronto-temporal atrophy, without senile lesions, characterized by personality changes of the frontal type, associated with verbal and behavioural stereotypies, and bulimia. Expand
Distribution of basal ganglia lesions in Pick's disease with Pick bodies: A topographic neuropathological study of eight autopsy cases
In Pick's disease with Pick bodies, the degree and distribution of the lesions within the basal ganglia differs from those reported in both ‘Pick's disease without Pick bodies’ and corticobasal degeneration (CBD), in which severe lesions were present in the pallidum. Expand
Classic and generalized variants of Pick's disease: A clinicopathological, ultrastructural, and immunocytochemical comparative study
Six sporadic cases of dementia with lobar atrophy and neuronal cytoplasmic inclusions (Pick's disease) could be separated into two groups on the basis of the involvement of subcortical structures,Expand