Picenadol in a Large Multicenter Dental Pain Study

@article{Goldstein1994PicenadolIA,
  title={Picenadol in a Large Multicenter Dental Pain Study},
  author={David J. Goldstein and Rocco L. Brunelle and Richard E. George and Stephen Andrew Cooper and Paul J. Desjardins and G. W. Gaston and G E Jeffers and L T Gallegos and Donald C. Reynolds},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1994},
  volume={14}
}
Study Objective. To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model. 
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Both picenadol and codeine were significantly more effective than placebo in reducing pain intensity and increasing total relief in patients with postoperative pain. Expand
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Picenadol (LY 150720) is a racemic mixture of an N-methyl-4-phenylpiperidine derivative, with agonist-antagonist opiate properties, with analgesic activity and a low order of toxicity. Expand
Comparison of picenadol, a new centrally acting oral analgesic, with codeine and placebo in patients with post operative pain
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Picenadol was found to be efficacious in producing analgesia in patients with postoperative pain and to have minimal adverse effects, and further investigation of this unique compound is warranted. Expand
Picenadol, a mixed opioid agonist/antagonist without κ opioid agonist activity in the rat urination test
Picenadol and its (+) and (−) isomers were compared to butorphanol and nalbuphine for their effects on urinary output in the normally hydrated rat. Butorphanol, a partial K agonist, increased urinary… Expand
Effects of picenadol (LY150720) and its stereoisomers on electric shock titration in the squirrel monkey.
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The data support previous suggestions that the antinociceptive properties of picenadol arise from mu agonist actions of the dextrorotatory isomer and that the levorotatories isomer acts to limit the efficacy of the racemate. Expand
Quantitative analysis of the interaction between the agonist and antagonist isomers of picenadol (LY150720) on electric shock titration in the squirrel monkey.
TLDR
Previous suggestions that the antinociceptive activity of picenadol resides in the d-isomer (LY136596) and that the l-isomers acts to limit the analgesic efficacy of the racemate are supported. Expand
Effects of LY150720 (picenadol), a novel mixed-action opioid, on schedule-controlled responding in the squirrel monkey
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The opioid LY150720 is a racemic mixture whose resolution results in a highly stereospecific separation of agonist and antagonist activity, and its effects were studied in squirrel monkeys whose responding was maintained under a multiple fixed-ratio 30-response fixed-interval 5-minute schedule of food presentation. Expand
Effects of picenadol and its agonist and antagonist isomers on schedule-controlled behavior.
The effects of picenadol and its (+)- and (-)-isomers were determined on the responding of pigeons under a multiple fixed-ratio (FR) 50-response, fixed-interval (FI) 5-min schedule of grain… Expand
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Picenadol, an opioid with mu- and delta-receptor affinity
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