Picenadol in a Large Multicenter Dental Pain Study

  title={Picenadol in a Large Multicenter Dental Pain Study},
  author={David J. Goldstein and Rocco L. Brunelle and R E George and Stephen Andrew Cooper and Paul J. Desjardins and G. W. Gaston and G E Jeffers and L T Gallegos and Donald C. Reynolds},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Study Objective. To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model. 
Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery.
Surgery for wisdom tooth removal resulted in substantial decreases in the serum concentration of ibuprofen enantiomers and a prolongation in the time to peak concentration, suggesting reduced absorption and altered metabolism are the likely cause of these changes.
Drug disease interactions: role of inflammatory mediators in pain and variability in analgesic drug response.
  • K. Kulmatycki, F. Jamali
  • Medicine, Biology
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2007
Patients with temporal mandibular joint disease with increased expression of interleukins prior to treatment demonstrate inadequate pain relief after administration of anti-TNF-.


Analgesic effect of picenadol, codeine, and placebo in patients with postoperative pain
Both picenadol and codeine were significantly more effective than placebo in reducing pain intensity and increasing total relief in patients with postoperative pain.
Picenadol, a mixed opioid agonist/antagonist without κ opioid agonist activity in the rat urination test
Picenadol is a mixed agonist/antagonist with potent μ‐opioid action in the (+) isomer and weak μ‐and κ‐antagonistaction in the (−) isomers, and nalbuphine is a Mixed agonist /antagonist without activity at κ receptors.
Effects of picenadol (LY150720) and its stereoisomers on electric shock titration in the squirrel monkey.
The data support previous suggestions that the antinociceptive properties of picenadol arise from mu agonist actions of the dextrorotatory isomer and that the levorotatories isomer acts to limit the efficacy of the racemate.
Effects of picenadol and its agonist and antagonist isomers on schedule-controlled behavior.
The effects of picenadol and its (+)- and (-)-isomers were determined on the responding of pigeons under a multiple fixed-ratio (FR) 50-response, fixed-interval (FI) 5-min schedule of grain
  • Drug Alcohol Depend
  • 1985