Picenadol in a Large Multicenter Dental Pain Study

@article{Goldstein1994PicenadolIA,
  title={Picenadol in a Large Multicenter Dental Pain Study},
  author={David J. Goldstein and Rocco L. Brunelle and R E George and Stephen Andrew Cooper and Paul J. Desjardins and G. W. Gaston and G E Jeffers and L T Gallegos and Donald C. Reynolds},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1994},
  volume={14}
}
Study Objective. To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model. 
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Both picenadol and codeine were significantly more effective than placebo in reducing pain intensity and increasing total relief in patients with postoperative pain.
Picenadol, a mixed opioid agonist/antagonist without κ opioid agonist activity in the rat urination test
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Picenadol is a mixed agonist/antagonist with potent μ‐opioid action in the (+) isomer and weak μ‐and κ‐antagonistaction in the (−) isomers, and nalbuphine is a Mixed agonist /antagonist without activity at κ receptors.
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