Piccolo, a Presynaptic Zinc Finger Protein Structurally Related to Bassoon

Abstract

Piccolo is a novel component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release. Analysis of its primary structure reveals that Piccolo is a multidomain zinc finger protein structurally related to Bassoon, another PCM protein. Both proteins were found to be shared components of glutamatergic and GABAergic CNS synapses but not of the cholinergic neuromuscular junction. The Piccolo zinc fingers were found to interact with the dual prenylated rab3A and VAMP2/Synaptobrevin II receptor PRA1. We show that PRA1 is a synaptic vesicle-associated protein that is colocalized with Piccolo in nerve terminals of hippocampal primary neurons. These data suggest that Piccolo plays a role in the trafficking of synaptic vesicles (SVs) at the active zone.

DOI: 10.1016/S0896-6273(00)80883-1

Extracted Key Phrases

6 Figures and Tables

050100150'01'03'05'07'09'11'13'15'17
Citations per Year

922 Citations

Semantic Scholar estimates that this publication has 922 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Fenster2000PiccoloAP, title={Piccolo, a Presynaptic Zinc Finger Protein Structurally Related to Bassoon}, author={Steven D Fenster and Wook Joon Chung and Rong Zhai and Claudia Cases-Langhoff and Britta Voss and Abigail M Garner and Udo Kaempf and Stefan Kindler and Eckart D Gundelfinger and Craig C Garner}, journal={Neuron}, year={2000}, volume={25}, pages={203-214} }