• Chemistry, Medicine
  • Published in Journal of natural products 2001
  • DOI:10.1021/np010161w

Pibocin B, the first N-O-methylindole marine alkaloid, a metabolite from the Far-Eastern ascidian Eudistoma species.

@article{Makarieva2001PibocinBT,
  title={Pibocin B, the first N-O-methylindole marine alkaloid, a metabolite from the Far-Eastern ascidian Eudistoma species.},
  author={Tatyana N Makarieva and Andrey S Dmitrenok and Pavel S Dmitrenok and Boris B. Grebnev and Valentin A Stonik},
  journal={Journal of natural products},
  year={2001},
  volume={64 12},
  pages={
          1559-61
        }
}
Pibocin B (2), the first representative of marine alkaloids with a unique structural feature, an N-O-methylindole group, was isolated from the Far-Eastern ascidian Eudistoma sp. Its structure has been established as (8 beta)-2-bromo-N-O-methyl-6,8-dimethylergoline on the basis of NMR data, FAB and MALDI-TOF MS, and chemical correlations. Pibocin B showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells. 

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