Phytosterols and vascular disease

@article{John2006PhytosterolsAV,
  title={Phytosterols and vascular disease},
  author={S. John and A. Sorokin and P. Thompson},
  journal={Current Opinion in Lipidology},
  year={2006},
  volume={18},
  pages={35–40}
}
Purpose of review Phytosterols and stanols are plant derivatives that compete with cholesterol for intestinal absorption and thereby lower serum cholesterol concentrations. They have been developed as food additives to help lower serum cholesterol but there is concern that these additives could inadvertently increase cardiovascular risk. This concern arises from the observation that patients with the rare genetic condition phytosterolemia overabsorb phytosterols and develop premature… Expand
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References

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TLDR
Present evidence is accumulating to promote plant sterols and stanols use for lowering LDL cholesterol levels, as a first line of therapy (as well as adjunctive therapy) in patients on statin therapy. Expand
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TLDR
The results of this study do not support an association between elevated plasma levels of plant sterols and atherosclerosis, despite the fact that cholesterol levels were significantly higher in subjects with coronary calcium. Expand
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TLDR
The hypothesis that plant sterols might be an additional risk factor for coronary heart disease (CHD) in nonphytosterolemia subjects is supported. Expand
Dietary Phytosterols Reduce Cyclosporine-Induced Hypercholesterolemia in Apolipoprotein E-Knockout Mice
TLDR
This study suggests that simultaneous consumption of dietary phytosterols and cyclosporine may attenuate posttransplant hypercholesterolemia associated with the immunosuppressive cyclospora. Expand
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TLDR
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TLDR
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TLDR
The higher the absorption of cholesterol, the higher are the plant sterol contents in serum resulting also in their higher contents in atherosclerotic plaque. Expand
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TLDR
Serum C correlated with CAMP, STIG, SIT, and total P, and high serum CAMP and STIG were associated with a personal or family history of CHD in subjects less than or equal to age 55 years (premature CHD). Expand
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TLDR
Ezetimibe produced significant and progressive reductions in plasma plant sterol concentrations in patients with sitosterolemia, consistent with the hypothesis that ezetIMibe inhibits the intestinal absorption of plant sterols as well as cholesterol, leading to reduction in plasma concentrations. Expand
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