Phytosterols and vascular disease

@article{John2006PhytosterolsAV,
  title={Phytosterols and vascular disease},
  author={Saji Kaithavalappil John and Alexey V Sorokin and Paul D. Thompson},
  journal={Current Opinion in Lipidology},
  year={2006},
  volume={18},
  pages={35–40}
}
Purpose of review Phytosterols and stanols are plant derivatives that compete with cholesterol for intestinal absorption and thereby lower serum cholesterol concentrations. They have been developed as food additives to help lower serum cholesterol but there is concern that these additives could inadvertently increase cardiovascular risk. This concern arises from the observation that patients with the rare genetic condition phytosterolemia overabsorb phytosterols and develop premature… 

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TLDR
The results of this study do not support an association between elevated plasma levels of plant sterols and atherosclerosis, despite the fact that cholesterol levels were significantly higher in subjects with coronary calcium.

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TLDR
The hypothesis that plant sterols might be an additional risk factor for coronary heart disease (CHD) in nonphytosterolemia subjects is supported.

Dietary Phytosterols Reduce Cyclosporine-Induced Hypercholesterolemia in Apolipoprotein E-Knockout Mice

TLDR
This study suggests that simultaneous consumption of dietary phytosterols and cyclosporine may attenuate posttransplant hypercholesterolemia associated with the immunosuppressive cyclospora.

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TLDR
Identification of the genetic defect to chromosome 2p21 may throw light on regulation of net dietary cholesterol absorption and lead to an advancement in the management of this important cardiovascular risk factor.

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TLDR
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TLDR
Ezetimibe produced significant and progressive reductions in plasma plant sterol concentrations in patients with sitosterolemia, consistent with the hypothesis that ezetIMibe inhibits the intestinal absorption of plant sterols as well as cholesterol, leading to reduction in plasma concentrations.
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