Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats.

@article{Draper1997PhytoestrogensRB,
  title={Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats.},
  author={Constanze Draper and Michael J Edel and Ian M Dick and Andrew Paul George Randall and Graeme B Martin and Richard L Prince},
  journal={The Journal of nutrition},
  year={1997},
  volume={127 9},
  pages={
          1795-9
        }
}
To examine a potential role for phytoestrogens in postmenopausal bone loss, the oophorectomized (OOX) rat model has been used in three studies to investigate the effects of the phytoestrogens coumestrol, zearalanol and a mixture of isoflavones on estrogen-dependent bone loss. In the studies of coumestrol and zearalanol, the rats were allocated to a control group, a phytoestrogen-treated group (1.5 micromol coumestrol or 3.1 mmol zearalanol twice per week, intramuscular) or, in the coumestrol… CONTINUE READING

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