Phytoestrogens possess a weak antioxidant activity on low density lipoprotein in contrast to the flavonoid quercetin in vitro in postmenopausal women

  title={Phytoestrogens possess a weak antioxidant activity on low density lipoprotein in contrast to the flavonoid quercetin in vitro in postmenopausal women},
  author={Eugenio Arteaga and P Villaseca and Auristela Rojas and Guillermo Marshall and Marcelo Bianchi},
  pages={397 - 403}
Background Phytoestrogens are a family of plant-derived compounds with weak estrogenic and antiestrogenic properties. The antioxidant capacity of phytoestrogens has been proposed as one of the important mechanisms that explain their health benefits. Objective To determine the in vitro potency of three phytoestrogens, ubiquitous in food, (biochanin A, daidzein and genistein) as antioxidants of low density lipoprotein (LDL) and to compare them with the well-established antioxidant actions of… Expand
Isoflavone daidzein possesses no antioxidant activities in cell-free assays but induces the antioxidant enzyme catalase.
The hypothesis that the antioxidative effects of isoflavones are caused indirectly by up-regulation of antioxidative enzymes, thereby lowering intracellular concentration of reactive oxygene species is examined. Expand
Dietary PUFA and flavonoids as deterrents for environmental pollutants.
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Soy isoflavones reduce electronegative low-density lipoprotein (LDL−) and anti-LDL− autoantibodies in experimental atherosclerosis
Soy isoflavones showed hypolipidemic effects and decreased the pro-inflammatory LDL− subfraction in blood plasma and aorta of hypercholesterolemic rabbits. Expand
Quantification of genistein and daidzein in two endemic Genista species and their antioxidant activity
In the current research, the total and free genistein and daidzein con- tents were determined in two endemic Genista species (G. sandrasica and G. vuralii) by an HPLC method. The highest amount ofExpand
Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein.
In human hepatoma cells daidzein at a non-toxic concentration increases the activity of humanCatalase and induces the transcription of the catalase gene via interaction with the proximal part of the promoter. Expand
The effects of Allium cepa L. (onion) and its active constituents on metabolic syndrome: A review
The objective in this review was to find out the role of A. cepa and its bioactive phytochemicals as cardiovascular protective agents in different metabolic syndrome risk factors, including hyperlipidemia, high blood glucose, obesity, and hypertension. Expand
Effects of genistein on oxidative injury in endothelial cells.
Genistein protects vascular endothelial cells against the pro-atherosclerotic stressor, oxidized low-density lipoprotein (ox-LDL), by inducing antioxidant enzymes and preventing apoptosis, and is associated with maintenance of antioxidant enzyme activities and inhibition of lipid peroxidation. Expand
The impact of combined nutraceutical supplementation on quality of life and metabolic changes during the menopausal transition: a pilot randomized trial
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Phytoestrogen content of foods--a compendium of literature values.
Medians among reported values of phytoestrogen content are provided for some of the most commonly eaten foods with quantitative data available and may be used to calculate dietary intake of daidzein, genistein, coumestrol, formononetin, and biochanin A. Expand
In Vitro Effect of Estradiol, Progesterone, Testosterone, and of Combined Estradiol/Progestins on Low Density Lipoprotein (LDL) Oxidation in Postmenopausal Women
The results demonstrate that, in contrast with the potent antioxidant effect of estradiol, progesterone and testosterone did not show any pro- or antioxidant effect on low density lipoprotein in vitro. Expand
Structure-antioxidant activity relationships of flavonoids and phenolic acids.
The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase. Expand
Absorption and antioxidant effects of quercetin from onions, in man
Quercetin can be absorbed in humans from dietary sources to high enough concentrations to increase the overall antioxidant activity of the plasma, but has a strong affinity for protein and provides no direct protective effect during LDL oxidation. Expand
Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence.
Accumulating evidence suggests that phytoestrogens may potentially confer health benefits related to cardiovascular diseases, cancer, osteoporosis, and menopausal symptoms, and these potential health benefits are consistent with the epidemiological evidence that rates of heart disease, various cancers, osteopsorotic fractures, andMenopausal symptoms are more favorable among populations that consume plant-based diets. Expand
Effect of antioxidants on oxidative modification of LDL.
The efficiency of vitamin E-dependent (= k) and the vitamin independent (= a) oxidation resistance seem to be subject specific with strong individual variation. Expand
Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity--a controlled crossover trial.
Plant-derived estrogen analogs (phytoestrogens) may confer significant health advantages including cholesterol reduction, antioxidant activity, and possibly a reduced cancer risk. However, theExpand
Flavonoid intake and risk of chronic diseases.
The risk of some chronic diseases may be lower at higher dietary flavonoid intakes, and a trend toward a reduction in risk of type 2 diabetes was associated with higher quercetin intakes. Expand
Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene.
Long-term supplementation with large doses of vitamin E alone, but not beta-carotene, conferred increased protection to LDL in in vitro assays of oxidation, supporting the hypothesis that oxidation of low density lipoprotein (LDL) appears to be important in mediating the atherogenicity of LDL. Expand
Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders
Overall, there is a growing scientific rationale for the use of dietary supplements as adjuncts in the treatment of inflammatory disorders such as rheumatoid arthritis and osteoarthritis. Expand