Phytoestrogens and breast cancer: a complex story

@article{Helferich2008PhytoestrogensAB,
  title={Phytoestrogens and breast cancer: a complex story},
  author={W. Helferich and J. E. Andrade and M. Hoagland},
  journal={Inflammopharmacology},
  year={2008},
  volume={16},
  pages={219-226}
}
  • W. Helferich, J. E. Andrade, M. Hoagland
  • Published 2008
  • Biology, Medicine
  • Inflammopharmacology
  • Abstract.Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive compounds can modulate genistein-stimulated oestrogen-dependent tumour growth. Our research has focused on the effects of dietary genistein on the growth of oestrogen (E… CONTINUE READING
    154 Citations
    Coexposure to phytoestrogens and bisphenol a mimics estrogenic effects in an additive manner.
    • 46
    • PDF
    Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks.
    • 82
    A CHEMOPREVENTIVE FACTOR IN PROSTATE CANCER
    Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats
    • 23
    • PDF

    References

    SHOWING 1-10 OF 122 REFERENCES
    Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro.
    • 476
    Phytoestrogens: End of a tale?
    • 157
    Genistein exerts multiple suppressive effects on human breast carcinoma cells.
    • 240
    Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner.
    • 306
    • PDF
    Genistein, a dietary-derived inhibitor of in vitro angiogenesis.
    • 754
    • PDF
    Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice.
    • 105
    • PDF