Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells.

@article{Mesiano1999PhytoestrogensAA,
  title={Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells.},
  author={S. Mesiano and S. Katz and J. Lee and R. Jaffe},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 7},
  pages={
          2443-8
        }
}
Phytoestrogens influence a variety of biological processes. As 17beta-estradiol alters adrenocortical cell function, we examined whether the dietary phytoestrogens, genistein and daidzein, have related effects. In cultured human fetal and postnatal adrenal cortical cells, genistein and daidzein (both 0.4-40 micromol/L) decreased ACTH-stimulated cortisol production to basal levels (ED50, 1-4 micromol/L). In the adult adrenocortical cell line, H295, genistein, daidzein, and 17beta-estradiol (10… Expand
In vitro effects of genistein and daidzein on the activity of adrenocortical steroidogenic enzymes in mature female pigs.
Genistein stimulates the hypothalamo-pituitary-adrenal axis in adult rats: morphological and hormonal study.
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