Phytoestrogen resveratrol suppresses steroidogenesis by rat adrenocortical cells by inhibiting cytochrome P450 c21-hydroxylase.

@article{Supornsilchai2005PhytoestrogenRS,
  title={Phytoestrogen resveratrol suppresses steroidogenesis by rat adrenocortical cells by inhibiting cytochrome P450 c21-hydroxylase.},
  author={Vichit Supornsilchai and Konstantin V Svechnikov and Dana Seidlov{\'a}-Wuttke and Wolfgang Wuttke and Olle S{\"o}der},
  journal={Hormone research},
  year={2005},
  volume={64 6},
  pages={280-6}
}
BACKGROUND AND AIM The phytoestrogen resveratrol is found in grapes, mulberries and peanuts, all of which are consumed regularly by humans. Resveratrol is also used in chemotherapy against cancer and aging and as a cardioprotectant. The aim of the present study was to characterize the effects of resveratrol on rat adrenal steroidogenesis and to study the underlying mechanism. METHODS Adrenocortical cells were isolated from the adrenal glands of normal male rats (in vitro) and from male rats… CONTINUE READING
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