Phytoestrogen Content and Estrogenic Effect of Legume Fodder

  title={Phytoestrogen Content and Estrogenic Effect of Legume Fodder},
  author={Hannu Saloniemi and Kristiina W{\"a}h{\"a}l{\"a} and P{\"a}ivi Nyk{\"a}nen-Kurki and Kaarlo Kallela and Ilkka Saastamoinen},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={13 - 17}
Abstract This study is a summary of Finnish investigations of the phytoestrogen content of legume plants, red clover, white clover, alfalfa, and goat's rue. In addition to the chemical analyses, biological studies were performed. Uterine weight of immature rats was used as an indicator of the estrogenic effect of the fodder used. All red clover varieties studied contained estrogenic isoflavones, especially formononetin and biochanin-A. The phytoestrogen content varied from 1.0% to 2.5% of dry… 

Tables from this paper

Effect of forage on the content of phyto-oestrogens in bovine milk.

The concentration of phyto-oestrogens in bovine milk is low compared to food sources rich in phy to-Oestrogens but the high concentration of equol could possibly be of therapeutic importance.

Phytoestrogen content of foods--a compendium of literature values.

Medians among reported values of phytoestrogen content are provided for some of the most commonly eaten foods with quantitative data available and may be used to calculate dietary intake of daidzein, genistein, coumestrol, formononetin, and biochanin A.

Effect of mycorrhization on the isoflavone content and the phytoestrogen activity of red clover.

Biochemical and Molecular Action of Nutrients Research Communication Trifolium pratense (Red Clover) Exhibits Estrogenic Effects In Vivo in Ovariectomized Sprague-Dawley Rats

Data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model, and neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied.

Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy?

Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.

Genistein was found to be the most effective of four red clover isoflavones tested in the above in vitro assays, suggesting a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.

Phytoestrogen Content of Birdsfoot Trefoil and Red Clover: Effects of Growth Stage and Ensiling Method

The phytoestrogen content of birdsfoot trefoil and red clover raw material and silage and the effects of growth stage, wilting and ensiling additives on content were studied.

Fresh and ensiled forages as a source of estrogenic equol in bovine milk: a review.

Cow’s milk was proved to be an important source of equol produced from the IF in the rumen and intestines, and red clover (Trifolium pratense) is by far the most important sources of both the IF and its contents.

The Effect of Trifolium pratense L. (Red Clover) on Rat Testes

Trifolium pretense L. in the diet was found to have a short term positive effect on pupertal spermatogenesis but a negative effect on it in the long term, compared with the well characterized exogenous estrogen 17-β estradiol.

Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.

Data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model, and neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied.



The effect of storage on the estrogenic effect of red clover silage.

  • K. Kallela
  • Biology, Medicine
    Nordisk veterinaermedicin
  • 1975
The estrogenic effect of the silage fodder made from the red clover of 1973 varied considerably; in some samples it was greater but in most it was smaller than the estrogen effect ofThe fresh red clovers of 1972.

The oestrogenic isoflavones of subterranean clover

A method of thin-layer chromatography has been developed which allows a rapid semiquantitative estimation of the main isoflavones present in this species of subterranean clover.

Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet.

The urinary excretion of lignans was low but that of the isoflavonoids was very high and correlated with soybean-product intake, suggesting that the low mortality in breast and prostate cancer of Japanese women and men may be due to the high intake of soybean products.

Plant oestrogens; the cause of decreased fertility in cows. A case report.

During the stall feeding period 1982-1983, it was established that serious fertility disturbances, indicating oestrogenic stimulation, had occurred in a herd of cattle in an area supported by the

Dietary fiber, phytoestrogens, and breast cancer.

There is mounting evidence that dietary fiber has a protective effect and may favorably modify the enhanced breast cancer risk associated with the typical American high-fat low-fiber diet.

Variations in the Content of Plant Oestrogens in Red Clover-Timothy-Grass during the Growing Season

A strong correlation between the plant oestrogen and crude protein contents of red clover is found, apparently both are due much to the same factors despite their divergent chemical compositions.

The effect of plant development and environment on formononetin concentration in red clover (Trifolium pratense L.)

Formononetin concentration in red clover herbage, determined by high performance liquid chromatography, was assessed in field, greenhouse and growth cabinet experiments. Formononetin content

Varietal variation in the isoflavone content of subterranean clover: Its estimation by a microtechnique

The isoflavone content of 46 subterranean clover varieties was estimated by a microtechnique which allowed of the semiquantitative analysis of 100 leaf samples per day. The relative proportions of