Phytoestrogen α-zearalanol exerts antiapoptotic effects in differentiated pc12 cells via oestrogen receptor α.

@article{Dong2015PhytoestrogenE,
  title={Phytoestrogen α-zearalanol exerts antiapoptotic effects in differentiated pc12 cells via oestrogen receptor α.},
  author={Yi Long Dong and Yan Wang and Hong Yang and Xiao Zhou Yang and Hai Jing Yu},
  journal={Basic & clinical pharmacology & toxicology},
  year={2015},
  volume={116 2},
  pages={110-4}
}
Our previous studies have demonstrated that phytoestrogen α-zearalanol (α-ZAL) possesses potential benefits in alleviating cell apoptotic death just like oestrogen. However, the underlying mechanism is not fully understood. This study was designed to test the hypothesis that the neuroprotective effect of α-ZAL is mediated by oestrogen receptor (ER) as α-ZAL owns the benzene ring structure may interact with ER. The present results showed a significant increase in apoptosis in differentiated PC12… CONTINUE READING