Phytoecdysteroids from Ajuga macrosperma var. breviflora roots.

  title={Phytoecdysteroids from Ajuga macrosperma var. breviflora roots.},
  author={Amaya Castro and J. Coll and Yudelsy A. Tandr{\'o}n and Anil Kumar Pant and Chandra Shekhar Mathela},
  journal={Journal of natural products},
  volume={71 7},
Three new phytoecdysteroids, ajugacetalsterones C (1) and D (3) and breviflorasterone (2), were isolated from the roots of Ajuga macrosperma var. breviflora along with five known compounds, namely, 20-hydroxyecdysone, cyasterone, makisterone A, 20-hydroxyecdysone 3-acetate, and 20-hydroxyecdysone 2-acetate. The structures of 1-3 were elucidated on the basis of extensive 1D and 2D NMR spectroscopic studies. The new compounds possess acetal oxygen bridges between C-26 and C-20/C-22, or C-26/C-23… 
Bioactive neo-clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge.
Ten new neo-clerodane diterpenes, ajugaciliatins A-J, along with 17 known analogues, were isolated from the whole plants of Ajuga ciliata Bunge and exhibited moderate neuroprotective effects against MPP(+)-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells.
Phytochemical, cytotoxic and chemotaxonomic study on Ajuga forrestii Diels (Labiatae)
This is the first report of compounds 1–14 from A. forrestii, including eight neo-clerodane diterpenes, two phytoecdysteroids, one stigmastane sterol and three iridoid glycosides.
neo-Clerodane Diterpenoids from Ajuga macrosperma var. breviflora
Six new naturally occurring ajugarin-like neo-clerodane diterpenoids, ajugaflorins A-F, along with six known compounds, were isolated from A. breviflora by extensive NMR spectroscopic and MS analyses and comparison with data previously reported.
Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha.
Eight new neo-clerodane diterpenoids were acquired from the aerial parts of Ajuga pantantha and the more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins as well as their binding interactions with the two proteins.
Ecdysteroid Profiles of Two Ajuga species, A. iva and A. remota
The isolation and identification of major and minor ecdysteroids present in two Ajuga species, A. iva and A. remota, both of which are used as medicinal plants in Africa, are reported.
Major Constituents and Cytotoxic Effects of Ajuga chamaecistus ssp. tomentella
The results of this study suggest that melilotoside, phenylethyl glycosides, and phytoecdysteroids are the main constituents of the n-butanolic fraction of Ajuga chamaecistus ssp.
Ethnopharmacology of the plants of genus Ajuga.
Members of the genus Ajuga have been used in traditional medicine as a remedy for fever, toothache, dysentery, malaria, high blood pressure, diabetes, gastrointestinal disorders, as anthelmintic, diuretic and antifungal, anti-inflammatory, and antimycobacterial agents and are also used as insect growth inhibitor s.
Chemical and pharmacological research on the plants from genus Ajuga
This review summarizes the phytochemical progress of the genus Ajuga and lists the compounds isolated up to 2014.