Phytocomponent 4-hydroxy-3-methoxycinnamaldehyde ablates T-cell activation by targeting protein kinase C-θ and its downstream pathways.

@article{Akber2015Phytocomponent4A,
  title={Phytocomponent 4-hydroxy-3-methoxycinnamaldehyde ablates T-cell activation by targeting protein kinase C-θ and its downstream pathways.},
  author={Uroos Akber and Bo-Ra Na and Yoo-Seung Ko and Hyun-Su Lee and Hye Ran Kim and Min-Sung Kwon and Zee-Yong Park and Eun-Ju Choi and W Han and Seung-Ho Lee and Hyun Mee Oh and C. Blattn{\'y} Jun},
  journal={International immunopharmacology},
  year={2015},
  volume={25 1},
  pages={130-40}
}
Autoreactive T-cell responses have a crucial role in the pathology and clinical course of autoimmune diseases. Therefore, controlling the activation of these cells is an important strategy for developing therapies and therapeutics. Here, we identified that 4-hydroxy-3-methoxycinnamaldehyde (4H3MC) has a therapeutic potential for T-cell activation by modulating protein kinase C-θ (PKCθ) and its downstream pathways. Pre- and post-treatment with 4H3MC prevented IL-2 release from human transformed… CONTINUE READING
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