Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage.

@article{Duursen2004PhytochemicalsIC,
  title={Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage.},
  author={Majorie B M van Duursen and J Thomas Sanderson and Paul Chr de Jong and Marlies Kraaij and Martin H Van Den Berg},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={81 2},
  pages={316-24}
}
Phytochemicals are natural dietary constituents of fruits and vegetables. Some of these phytochemicals are known to affect estrogen-metabolizing enzymes. In breast tissue, estradiol can be metabolized to the catechol estrogens 2- and 4-hydroxyestradiol (2-OHE(2) and 4-OHE(2)). Catechol estrogens are suspected carcinogens potentially involved in the etiology of breast cancer. Catechol-O-methyltransferase (COMT) converts the catechol estrogens to their inactive methoxy derivatives (2-MeOE(2) and… CONTINUE READING

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