Phytochemicals for breast cancer prevention by targeting aromatase.

@article{Adams2009PhytochemicalsFB,
  title={Phytochemicals for breast cancer prevention by targeting aromatase.},
  author={Lynn S. Adams and Shiuan Chen},
  journal={Frontiers in bioscience},
  year={2009},
  volume={14},
  pages={
          3846-63
        }
}
Aromatase is a cytochrome P450 enzyme (CYP19) and is the rate limiting enzyme in the conversion of androgens to estrogens. Suppression of in situ estrogen production through aromatase inhibition is the current treatment strategy for hormone-responsive breast cancers. Drugs that inhibit aromatase have been developed and are currently utilized as adjuvant therapy for breast cancer in post-menopausal women with hormone dependent breast cancer. Natural compounds have been studied extensively for… Expand
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