Phytochemicals as potential IKK-β inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones

@article{Hua2019PhytochemicalsAP,
  title={Phytochemicals as potential IKK-$\beta$ inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones},
  author={Fang Hua and Lingli Shi and Peng Zhou},
  journal={Inflammopharmacology},
  year={2019},
  volume={28},
  pages={83-93}
}
Modulation of inhibitor kappa B kinase-beta (IKK-β) kinase activity could be useful for preventing inflammation that serves an efficient role in protection against cardiovascular diseases (CVDs). IKK-β induces inflammation by activating transcription factor NF-kappa B (NF-κB) through phosphorylation of IκB. Therefore, IKK-β is considered an interesting target for protecting and treating CVDs. The cardioprotective potential of terpenoids, alkaloids and quinines may be related to modulating… 

Therapeutic potential and research progress of diosgenin for lipid metabolism diseases.

This systematic review will briefly describe the advantages of diosgenin as a potential therapeutic drug and seek to enhance the understanding of the pharmacological mechanism, recipe-construction, and the development of novel therapeutics against lipid metabolism diseases.

Roles of ginsenosides in sepsis

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

The CVD therapy efficacy of 92 plants, including 15 terrestrial plants, is examined and several physiologically active compounds with recognized biological effects have been found in various plants because of the increased prevalence of CVD, appropriate CVD prevention and treatment measures are required.

References

SHOWING 1-10 OF 104 REFERENCES

Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

Folk medicine supports the studies which have demonstrated that plant-derived terpenoid ingredients can suppress nuclear factor-κB signaling, the major regulator in the pathogenesis of inflammatory diseases and cancer.

Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences

The results suggest that the IKKβ inhibition is the major mechanism of the PTs-induced NF-κB inhibition.

IKK-beta inhibitors: an analysis of drug-receptor interaction by using molecular docking and pharmacophore 3D-QSAR approaches.

Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways

The anti-inflammatory effects of artemisinin in TPA-induced skin inflammation in mice were demonstrated and it was proved that art Artemisinin potentiated TNF-α-induced apoptosis.

Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways

Mechanistically, CTS inhibited markedly the phosphorylation of mitogen-activated protein kinases (MAPKs), including ERK1/2, p38MAPK, and JNK, which are crucially involved in regulation of proinflammatory mediator secretion.

Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages.

The data suggest that emodin plays its anti-inflammatory roles by regulating inflammatory cytokines, specifically by suppressing NF-kappaB activation.

Sanguinarine Attenuates Lipopolysaccharide-induced Inflammation and Apoptosis by Inhibiting the TLR4/NF-κB Pathway in H9c2 Cardiomyocytes

It was suggested that SAN suppressed the LPS-induced inflammation and apoptosis of H9c2 cardiomyocytes, which may be mediated by inhibition of the TLR4/NF-κB signaling pathway, and may be a feasible therapy to treat sepsis patients with cardiac dysfunction.

Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor-κB Activation

The results showed that PL significantly and dose-dependently suppressed the paw edema of rats induced by carrageenan and various proinflammatory mediators, including histamine, serotonin, bradykinin, and prostaglandin E2 and suggests that PL has a potential to be developed into an anti-inflammatory agent for treating inflammatory diseases.
...